Registration

THE SCHOOL OF THEORETICAL MODELING

     DEPARTMENT OF BIOPHYSICS

     DEPARTMENT OF BIOCHEMISTRY

     DEPARTMENT OF MOLECULAR MODELING

     DEPARTMENT OF MATHEMATICAL/STATISTICAL ANALYSIS, ALGORITHM DESIGN AND PROGRAMMING

     DEPARTMENT OF BIONFORMATICS

 

SEMESTER AND SUMMER COURSES 

 

ADVANCED COURSES

 

MATHEMATICS                    STATISTICS                           CALCULUS

PHYSICS                                CHEMISTRY                          BIOLOGY

BIOCHEMISTRY                   PROTEIN CHEMISTRY        PROTEIN MODELING

PHOTOSYNTHESIS AND RESPIRATION

 

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ADVANCED COURSES FOR MIDDLE and HIGH SCHOOL STUDENTS

 

MATHEMATICS                    CALCULUS                            PHYSICS

CHEMISTRY                          BIOLOGY                               STATISTICS

 

- ADVANCED KNOWLEDGE OF SUBJECTS

- INCLUDES MAIN TOPICS OF SAT AND AP TESTS

- ENHANCEMENT OF STUDENTíS PERFORMANCE AT CURRENT SCHOOL

- PREPARES TOWARD COLLEGE ADMISSION

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ADVANCED COURSES FOR PROFESSIONAL DEVELOPMENT

 

MATHEMATICS                    CALCULUS                            PHYSICS

CHEMISTRY                          BIOLOGY                               STATISTICS

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SEMESTER COURSE  (40 HOURS) - $1200.00

SUMMER COURSE (40 HOURS) - $1200.00

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SAT COURSE  (10 HOURS) - $300.00

SAT COURSE  ( 5 HOURS) - $150.00

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 Courses are taking place in Washington, DC, at 1717 K street, NW

FOR INFORMATION E-mail: info@schtm.org   PHONE: (240) 381-2383

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APPLICATION FORM

 

COURSE TITLE   ______________________________________________________________________________

 

Studentís Name ________________________________________________________________________________

 

 Address  ______________________________________________________________________________________

 

Phone_________________________________________________________________________________________

e-mail to  info@schtm.org  or mail to P.O.Box 15676 Chevy Chase, MD 20825

 

     DEPARTMENT OF MOLECULAR MODELING

          PROTEIN MODELING COURSE

COURSE "PROTEIN MODELING" started in August 2002. It is currently taking place in Washington, DC, at 1717 K street, NW as one day course or weekly.

Course can be taken individually or in a group. Participants are welcome to suggest topics of their particular interest and bring to discussion practical applications they are working on. Course is supplemented by a text book and CD with examples.

 

 

 

 

     DEPARTMENT OF BIOPHYSICS

          Collaboration with The American Red Cross Laboratory Holland Laboratory

          Conformational Changes in Fibrin/Fibrinogen

     DEPARTMENT OF MATHEMATICAL/STATISTICAL ANALYSIS, ALGORITHM DESIGN AND PROGRAMMING

          Collaboration with CGH Technologies/FAA

 

 

 

 

Mailing Address:

The School of Theoretical Modeling

P.O.Box 15676, Chevy Chase, MD 20825

E-mail: info@schtm.org

Phone: (240) 381-2383

Web site http://www.schtm.org

 

 

 

 

 

 

 

 

 

 

 

THE SCHOOL OF THEORETICAL MODELING

.      DEPARTMENTS

.      RESEARCH

.      PROTEIN MODELING COURSE

.      SEMESTER AND SUMMER COURSES

     COURSES FOR MIDDLE AND HIGH SCHOOL STUDENTS

     SAT COURSE

     COLLABORATIONS

.      STAFF

.      CONTACT INFORMATION

.      PROTEIN MODELING COURSE

.      ONE DAY COURSE SCHEDULE

.      SPEAKER

.      REGISTRATION FORM

.

DEPARTMENTS 

COLLABORATIONS 
 CONTACT INFORMATION
 
     THE SCHOOL OF THEORETICAL MODELING        N. Kurochkina, Ph.D.
     ONE DAY COURSE
     PROTEIN MODELING
   
 
9:30-10:00

 

Organizing procedures

     Introduction of all participants

     Short introduction to the topics of the course

10-10:55

 

Protein conformation

     Parameters characterizing polypeptide chain

     Topology, orientation of protein secondary structure elements

11-11:55

 

New mathematical approaches to protein structure prediction/protein modeling

     Formula for spatial location of amino acid residues within secondary structure

     elements

     Application to the prediction of protein structure

     Algorithms

12-1:00

 

     Lunch

1-1:55

 

Description of helix-helix interfaces, active sites

     Structure comparison

     Specific side chain interactions

     Amino acid composition of helix-helix interfaces

     Variations among homologs and mutagenesis

     Disulfide bonds

Representing molecular forces affecting protein folding

Modeling of loops

Protein - nucleic acid interactions

2-2:55

 

Agonist/antagonist affects on binding sites

Conformational changes

Formation of channels

3-3:55

 

Application of modeling to the analysis of the protein families involved in desease pathogenesis

4-4:30

 

Organizing procedures

     Summarizing questions

     Concluding remarks

Course is supplemented by a text book and CD with examples

Course participants are welcome to suggest topics of individual (group) interest during registration (For each session or following course discussions and practical applications)

   
                                                                    All Rights Reserved  
   
BIOGRAPHICAL INFORMATION

 

Natalya Kurochkina received her Ph.D. in Physical and Mathematical Sciences (Biophysics) in October 1990 from the Institute of Protein Research/Institute of Biophysics, Pushchino, Russian Academy of Sciences. She worked as NIH Visiting Fellow in the Laboratory of Molecular Biology of the National Cancer Institute, National Institutes of Health in Bethesda, Maryland from 1991 to 1996. After that she had a position as a Research Scientist at Applied Thermodynamics in Hunt Valley, Maryland from 1996 to 1998. Currently N.A.Kurochkina is working as Director of a School of Theoretical Modeling, Chevy Chase, Maryland. She is a member of Biophysical Society, American Association for the Advancement of Science. During this time she was working on development of methods for interpretation of electron density maps at high atomic resolution, molecular cartography, analysis of conformations with interpeptide ionic bridges, computer modeling of the process of translocation of proteins via membrane, simulation of the process of folding for peptides and proteins using Monte Carlo methods, development of hydrophobic potential based on pair-wise surface area sum for the estimation of nonpolar groups contribution in the process of folding, method for the prediction of topology for two topological groups of the four- helix bundle motif, design of antibodies with new properties, analysis of heterogeneity of packing, development of a model of protein channel, studies of conformational changes and exposure of epitopes in fibrin. Recent publications describe formula for spatial location of amino acids within secondary structure elements and its application to the prediction of protein structure, regularities in fragmentation of protein interior with respect to signal transduction, similarities found for the family of proteins with leucine repeats.

SELECTED PUBLICATIONS

 

     N. Kurochkina. Amino acid composition of parallel helix-helix interfaces. J. Theoretical Biology, (2007). In Press.

link: http://dx.doi.org/10.1016/j.jtbi.2007.02.001 .

     S. Yakovlev, E. Makogonenko, N. Kurochkina, W. Nieuwenhuizen, K. Ingham, L. Medved. Conversion of fibrinogen to fibrin: mechanism of exposure for tPA-plasminogen binding site. Biochemistry, (2000) 39, 15730.

     N.Kurochkina, G. Privalov. Heterogeneity of packing: Structural Approach. Protein Science (1998) 7:897-906 .

     U. Brinkmann, A. Di Carlo, G. Vasmatzis, N. Kurochkina, R. Beers, B. Lee, I. Pastan. Stabilization of a recombinant Fv Fragment by base loop interconnection and VH-VL permutation. J. Mol. Biol. (1997) v. 268, 107-117.

     B. Lee, N. Kurochkina, H.S. Kang. Protein folding by a biased Monte Carlo procedure

in the dihedral angle space. Faseb. J. (1996) v.10 (1), 119-125.

     N. Kurochkina, B. Lee. Hydrophobic potential based on pair-wise surface

area sum. Protein Engineering (1995), v.8, no.5, 437-442.

     N. Kurochkina, Kang, H. B. Lee. Experiences with dihedral angle space Monte Carlo

search for small protein structures. in: Statistical mechanics, protein structure and protein-substrate interactions. ed/S. Doniach. Plenum Press, 1994.

     H. S. Kang, N. A. Kurochkina and B. Lee. Estimation and Use of Protein Backbone Angle Probabilities. J. Mol. Biol. (1993) 229, 448-460.

     V. I. Lim, C. Venclovas, N. A. Kurochkina. The path of a protein chain can be approximated by the conformation dictated by interpeptide ionic bridges. FEBS Letters (1992) v.302, 57-60.

     N. A. Kurochkina, V. S. Lamsin, A. P. Savitsky, I. A. Shumilin and V. O.

Popov. Mapping of the immunodominant regions of the NAD-dependent formate

dehydrogenase. FEBS Letters (1990) v.260, pp.297-300.

     A. V. Bogdanova, T. V. Cherednikova, T. A. Egorov, E. G. Harutyunyan,

     Yu. N. Chirgadze, N. A. Kurochkina, S. V. Niconov. Molecular Cartography of Proteins: Surface Relief Analysis of Calf Eye Lens Protein Gamma-crystallin. Protein Engineering (1989) 3, pp.105-110.

     N. A. Nevskaya, N. A. Kurochkina, Yu. N. Chirgadze. The building of the three-dimensional protein structure in electron density maps using computer graphics. Crystallographia (1986) 31, pp. 303-311 (in Russian).

CURRENT RESEARCH INTERESTS

 

Structural determinants of cellular signal transduction

Interactions of Apolipoprotein E (ApoE) with the receptor molecule and lipids

Amyloid Precursor Protein (APP) functioning

Protein Structure

 

 

   
                                                                    All Rights Reserved  


REGISTRATION FORM

Workshop: PROTEIN MODELING

NAME ______________________________________________________

TITLE ______________________________________________________

ORGANIZATION _____________________________________________

ADDRESS ___________________________________________________

City ___________________State_______Zip Code____________________

PHONE ________________________FAX __________________________

E-MAIL ______________________________________________________

I would to participate in the following session(s):

One Day Workshop

    Date:_________________     Location:______________________________________________________________

I would to have the course for a group of ______ people in my organization

    Date:_________________     Location:______________________________________________________________

    ___________________________________________________________________________________________

    Contact person:_________________________________________________________________________________

(Make checks payable to The School of Theoretical Modeling)

For more information visit our web-site at http://www.schtm.com

Mail to: The School of Theoretical Modeling

P.O.Box 15676, Chevy Chase, MD 20825

e-mail: info@schtm.org

Phone: (240) 381-2383

Request information:

P.O.Box 15676

Chevy Chase, MD 20825

e-mail: info@schtm.org.

Phone: (240) 381-2383